ive shot a couple deer and pigs with a load very simular. I ate the animals if that gives you an idea of how they work. Make sure though of your bullet choise. In the 41 which to me is getting a bit small in diameter you want a good flat nosed bullet. Im not a fan of wfns but i do use them in the 41 to get a metplat near the size of an average 44 bullet.