Mine is the 4 5/8 length Ruger. Changed the grips to smooth rosewood from Ruger. Tried 4 different handloads and 4 different factory loads. The handloads varied in powder type and bullet weight. Unique, 2400, and Trail Boss. The factory loads were Winchester, Hornady, Speer, and DoubleTap.
Off sandbags at 25 yards, I could not get a satisfactory group until I tried the DoubleTap 180 jhp at 1150 fps according to the box. Group size was right at 1", center to center and required only 1 click up and 1 click right to be dead on. The DoubleTap round is supposed to be standard pressure, safe in any gun. I've used it exclusively in my Charter Arms 2.5, with no problem. Actually, penetration and expansion out of the short barrel exceeds that of the Remington Golden Saber in .45acp, as determined by testing.
I'm anxious to try that round from my Ruger on deer this season. 180 grains at 1150 fps will surely get it done.
If you have one of the new flattops, I suggest you at least try DoubleTap. It's not cheap, and it's not reminiscent of the Elmer Keith days, but it sure does shoot.