although i havent shot a moose, the 270 should do the job quite well. if it were me, i would use nosler 150 grain partitons, or 160 gr. partitions. the partitions might not be needed; but i wouldnt think using them would hurt your cause on these big fellas. i get my best velocities with imr 7828 and cci large rifle magnum primers. each gun is different; and the only way to even guess where your at is using a chrony. book velocities are only a crude referance. sometimes they are right on, other times they are way off. good luck from an envious sportsman!