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I've never used a guide for antelope. A few years ago I shot an antelope with my contender in one of the walk on areas around Casper. I had 2 rookies with me but they filled their tags in a couple days. The chamber of commerce in most towns in Wyoming may be able to help you with a list of land owners that allow hunting for a tresspass fee. You don't have to hunt opening day to have a good hunt. I perfer to hunt a week or so later, less people spooking them around.
If you are shooting a 30.06 or 270 or similar flat shooting caliber a 2" high zero at 100 yds should allow you to shoot dead on at least to 250yds. Many of the towns in Wyoming have rifle ranges where you can check your zero. Get a phone book for the area you want to hunt and check out hotels,sporting goods shops, rifle ranges, and talk to wildlife biologists for the areas you want to hunt.
A hunting tactic that works for me is to spot antelope far off and then find a way to sneak close behind a hill or in a ravine and then crawl into position for a shot. Antelope are always closer than you think. If it doesn't work I go looking for a different group of antelope. Take good binoculars!
Cheap long distance calling is one of the best tools to use on an antelope hunt. Observe antelope for awhile when you get out there so you can tell a large one. Good luck