The .410 may work well at close range, but the power drops off severely by 50 yards, by the time it arrives at 100 yds, it's about equal to a .380 pistol or 38 snubbie.:
http://www.winchester.com/products/shotshell-ammunition/super-x/slugs/Pages/X413RS5.aspx Here is an article concerning deer hunting with a .410 which has some good info as well as some bad. The bad info is (IMO) whare the author discusses ballistics. He tries to compare the .410 with the .357 & .41 mags...but he uses ballistics from a .410 shotgun with full length barrel and ballistics for .357 & .41 mag from a short barrelled handgun.."apples to oranges"..
http://mcb-homis.com/deer9410/index.htm To be fair it would seem, one should compare long gun to long gun, in which case there is a marked difference:
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Relative killing power at 100 yards, taken from the "
Guns and Shooting Online Rifle Cartridge Killing Power Formula and List" (see the Tables, Charts and Lists page):
.357 mag 158 grJHP.. 1830 fps
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I can understand if one wants to "tinker' with a .410, and Brenneke slugs may well help; but if one were to move up a notch, to a 20 guage..then we are talking about some real deer knockdown power. ..And it's not expensive to do if it's H&R..and you can find a barrel here on GBO classified.