Yes and no. Have to disagree with some posts. You can swap barrels with same frame numerous times and not have to re-zero. However if you use a
DIFFERENT frame you may have to re-zero. I have shot contenders for the better part of 25 years. I have had several occasions where sight adjustments had to be made, but only because barrel and frame were not matched.
All of my competition contender barrels have frame serial number painted on barrel lug. This way I match barrel to correct frame every time and no re-zero. A buddy and I shoot silhouette and several times something has happened where one of us had to borrow a frame, barrel, or sight from the other. Hammer spring tension, barrel lug height, frame thickness, etc all play a part and you
might have to make sight adjustments. Sometimes it is only one or two clicks on the iron sight and maybe a click or two on the scope, but it can happen.
He who has only one frame should have NO worries about repeatability.
Steve