The .17 is a GREAT cartridge, but I don't think coyote-size game was on the menu when it was designed. It is a much easier cartridge to hit with out to 200 yards than the .22 Mag, but I don't think it's appropriate for that large an animal. I woldn't take it fox hunting as a first choice, let alone coyotes. I know that you can kill just about anything with anything if the planets and starts are in perfect alignment with perfect shot placement, but that doesn't exactly make it a good idea.