I truly believe the .357 is plenty within 50-60 yards, and it is my preferred handgun for deer hunting. I prefer my deer to be within 40 yards, thats my comfort zone, 50 is reaching my outter limits. A bow is plenty within 40 yards
Like Lloyd says Shot placement is what makes a diffrence. There are all kinds of stories about stretched yardages, but they are exceptions "NOT RULES".
For example the 44mag is capable of killing a deer well past 100yards, maybe 150, but I am not capable of putting the bullet on target with a handgun at that distance, especially with iron sights.