If it is a well used revolver and the gap is exessive, I would try a new wedge first, and limit any fitting file work to the wedge first. If that didn't help I would then take a small file to the cylinder pin wedge slot, but only file on the slots front edge. I would scrutinize and think through Every aspect before filing on/in the cylinder pin. Wedges are the cheapest starting point, start there and go carefull. All adjustment is meant to be wedge pressure. Good luck.
Is it a brass frame?? If so, is it worn with cylinder indentation/imprinting marks on the recoil shield? If so, it's probably shot out. (Wallhanger or parts)...........