Depends on what you want. For plinking loads, I don't care what anyone says about being dirty, Bullseye is still king. Dirty, smirty, I've never had a pistol fail to fire from Bullseye loads, 500 at a time. For hotter loads, I like Unique. Why? I try to keep the number of powders on my bench to a minimum. Unique is, in my book, the most versital powder there is. I load 380, 9, 38, 357, 40, 45 ACP and 45 Colt with it, along with shot shells and reduced 45-70 loads. It excells with cast bullets in al calibers.