If the rifle is properly constructed, there should be no difference in "head space" issues between it and a TC, or any other single barrel. It either fits or not. I have a lot of Handi rifles, which are not claimed to be user "fittable", so I have to fit some barrels to the frame. Most of the time it's a piece of cake.
On guns with tighter mfg. tolerances, it should not be a problem at all....
Ben