Dand I like that.... so I'm gonna use it... I'm no expert, except that I live in alaska bear country...
First of all shooting through plastic and wood and paper and all that crap is dandy... but it doesn't reflect anatomy at all.
Second of all, if you do hit a large bone, it is going to shatter, and that is going to absorb a LOT of energy and your bullet won't be doing much after that. Especially out of a .45WM.
Next point - if you do shoot a big bear in the shoulder with a .45WM, or anything else for that matter, you are going to have a pissed of bear with a broken shoulder. - Which can still kill you without a half a seconds discussion. Thinking of any round going through a shoulder and hitting vitals is dumb. It's one or the other. I'm trying to break the shoulder, and then I finish him off --- or I'm trying to hit the vitals and kill him. (In a hunting sense)
From the sounds of it you are just talking about wasting time for yourself not a real situation you plan to be in.
I've drawn on bears and luckily haven't had to shoot any in defense, but let me tell you where I aim. - At the bear. That's right, there is no, aim for the shoulder or the brain or the heart or the whatever else. In that situation the only place to aim is dead center mass, because you are most likely to hit something.
Now since you did mention hunting.... Your shoulder shot with a pistol is a bad idea. A large caliber magnum rifle, yes, you can break the living $%&^ out of the shoulder and anchor him then kill him.
Can you break a rib and go through vitals with that round? Yes you can. That's the shot you want.
Go and look up some anatomy diagrams. A bear ain't a deer.