beng,
I have one 45-70 that it sighted in with Lee 405 grain HBs over either 700x or Unique. These two Loads are equalivant velocity, right at 1,000 fps or upper subsonic. They are a hoot to shoot, I had a friend's 14 year old launching them the other day at the range, and he was happy!
A word of caution using fast burning powders in large capacity cases, you have to have a system in place to prevent a double or triple charge, just like when you use these powders in many of the pistol calibers.
BB