I would have some concern about penetration with a 200 gr, but only if you hit some heavy bone going into the animal. However, best accuracy requires a 230 gr or heaver with the LFN, so I would recommend a 230 or 240 gr, to keep the wound diameter up for a rapid kill. I recommned more DV up to a max of 135 or so. The above weights should get enough velocity to get a DV well over 100 which seems to kill at about the same speed as DV's up to 135. A 100 DV will punch a solid one inch diameter hole straight through on broadside or somewhat angled broadside hits with game of caribou size, and they just don't have enough blood to flood that size hole for more than a few seconds.
Penetration of hard, non expanding bullets is so good that we don't have to worry much about having enough weight for complete penetration in game of the size you are talking about. If it has enough weight (bearing length) to be accurate , it will have enough weight to penetrate, especially with the power level you have your hands on.
I have received quite a few reports from customers using the 45 ACP on deer and bear with excellent results, none of them even mentioning penetration. They simply all stated that it had enough power to anchor their deer and bear. This with the LFN in weights around 220 230 gr.
