I like the idea too. If the purpose was for a switch barrel setup, then head spacing would have to be considered. May i suggest a system similar to a Savage bolt gun? Have a flange that would mate into a groove in the mono block at the breech end with a barrel nut the would mate with threads on the barrel at the front of the mono block. The barrel would be inserted into the mono block from the breech end, the barrel nut over the muzzle and threaded onto the barrel to tighten every thing up. This way, every time you switch a barrel, the head spacing would be the same, it would not have to be dependant on thread torquing. The barrel could easily be indexed for the extractor/ejector and fore end screw or even iron sights.
Good Luck and Good Shooting