Unfortunately, I have no game killing experience with either of the 2 bullets you mention, so I may not be much help. I have 2 .375 JDJ barrels, and have owned the oldest one 23 years, having hunted with it on 4 continents.
I long ago settled on the 220 FN, 270 Spire and 300 gr. FMJ Hornadys for my use, depending upon the game being hunted. I use H 4895 with the 220, and AA 2520 with the 270 and 300.
For small thin skinned game like deer, I recommend the 220 Hornady. A friend with a great deal of experience claims the 225 is too hard for small animals, but as I said, I have no personal experience with it.
In Africa, where one may encounter a 20 lb. steenbok or an 1800 lb. buffalo, I use and have been satisfied with the 270 on animals throughout that weight range.
I also have used and would recommend the 270 gr. for bears. I have only used the 300 gr. FMJ for follow-up shots on Australian buffalo, where it worked fine.