Myself I went with the Hornady .45cal. XTP-MAG bullets in a .50 caliber sabot. With 100gr. Triple 7 (loose) I was getting consistent 2" groups at 100 yards.
Nailed a nice 8-point on the opening day here in AR. In the front of the right shoulder and out the left side ribcage. The heart and lungs looked like they had been through a blender. Oh, yeah, the buck dropped on the spot too. Needless to say, this is my load from now on!
Ranger413