Well, read some of Lloyd Smale's comments a few post back and as happens a fair amount of the time, I'll come down in agreement.
Early on, I responded to this post as a years long 300win Mag owner/shooter/hunter, stating that there is no such thing as too dead and that much of my answer to the "O.P." comes down to bullet integrity.
AS an example to the bullet integrity issue, and not trying to hijack or change the subject, I'll flesh out the integrity comment a bit more.
This past Friday afternoon, a friends buck was hanging in my shop when I got home from hunting, so he was called to let him know I was there to help and we soon got to the cleaning and skinning.
Now I'll agree that a shoulder hit is very bad bullet placement, but this is afterall, "hunting" and such things happen. Caliber, 45/70. But the major problem was the bullet used, The Hornady levereveloution gummy tip and the meat loss and distruction was extreme. UGLY!!!!!!!!!!! Both Shoulders!
I love my RUGER #1 - 45/70, but if there is one thing my cast, 465gr WFN bullet do not lack, it is integrity.
But then to make the picture and lack of bullet integrity crystal clear, on Monday there was a message for me when I again arrived home from hunting, another friend had a buck down and needed help.
We got the field work taken care of, got the critter to my place, washed out, hung and skinned and there we have it, another side to side shoulder hit.
BUT!!! And note the big, "BUT" this is where the picture takes a real change for the better.
This second buck was taken with the second friend's 30/06 with 165gr Nosler Partition loads I developed for him, Summer before last.
The impact velocity had to be a 1000fps faster with the 30/06 then with the 45/70, but Ooooooooh the huge difference in distruction and meat loss.
So, the point is, go with the 300 if that is what you have, but go to the field with typical cup-n-core bullets and have something less then a good side to side -BEHIND THE SHOULDER- hit and you may well loose LOTS!!! and lots of meat.
The Hornady gummy nose bullet is a very poor and soft product, suffering greatly from a shortage of bullet integrity, something which it hold in common with a good number of the cup-n-core production presently available.
Will they put a critter down? Most of the time yes, but this is after all, as stated, "hunting" and as such not all hits are text book perfect and you do get what you pay for in bullet quality/integrity.
If I wasn't having so much fun with my 45/70, I'd likely be hunting with my 300, but using a bullet made with integrity of design and construction was a lesson learned long ago.
Crusty Deary Ol'Coot