No way will I be happy with one rifle. I shot my first mule deer with a Win Mdl 70 270 in 1953. For some time I used the 270 for mule deer and pronghorn shooting. But for elk the 340 Weatherby is what I ended up using. For a while I used a 308 Norma Mag for mule deer, pronghorn, and elk shooting. For prairie dog shooting I started out with a 22 LR in 1949 followed by a 222 Rem. But over the years for varmints and preditors I have also used a 17 HM2, 17 HMR, 17 Fireball, 17 Rem, 204 Ruger, 22WMR, 22 Hornet, 221 Fireball, 223 Rem, 22-250 Rem, and 243 Win.Varity is the spice of life. I have two 30-06s rifle but never got around to use them for hunting. The 06 is a fine round and have seen big game shot with it. I still have to try out a 17 Hornady Hornet , I ll get on for my next birthday, 77 th year, but if I cant get one by then hope to have one by Christmas.