1) your rate of twist will indicate what length projectile will be likely max for stabilization. Weight is somewhat related, but a long pointy nose putting a lot of weight forward will still come down to the length, not necessarily the weight being the limiting factor there.
2) that projectile ojive will determine how far up-bore it can sit, and thus the amount of bullet in the case and thus case capacity.
3) your stabilization will also be affected by your velocity; ie, a sub-sonic heavy bullet will require more twist than a more typical velocity load 'in most cases'. Its a balancing act of bullet length, weight and velocity, not to mention the all important fit to the throat of the given chamber with cast bullets.
4) no need to re-invent the wheel; a lot of this kind of work has already been done, so rather than buy the wrong stuff use some of the proven heavy for caliber loads to gain some real world experience before venturing into rocket science.