I shoot a Winchester Model 70 Classic Featherweight in .270 caliber with 150 grain Nosler Partitions at 2,540 fps muzzle velocity from a steady rest at distances up to and including 222 yards. I don't use Nosler Ballistic Tips, Speer Grand Slams, Speer, Hornady, Federal, Winchester, etc., bullets because they don't shoot well in my rifle or they perform POORLY on the game when shot in the same place as the Partitions.
I am a meat hunter, a reloader and, by practice, an effective shot. I aim small and therefore miss small. I don't want to track. Like gstewart44, the swamp surrounding my east-central Florida woods is deep, thick, and unforgiving - but a HUGH Wildlife Pump. I shoot a LOT of FL hogs (500+ since 1989; 24/7/365) and few deer (except when I go to South Carolina and there shoot 4-7 deer annually - usually). I am happier when the game participates but satisfied for trying when they don't.
As a meat hunter, it does the game no good for it to linger in life after a bullet has been placed through its vitals. The "Primordial Soup" of chemistry that follows the shock of impact and Flight for Life taints the meat. For this purpose, putting an animal down DRT is significantly better than tracking a blood trail. I will head/neck shoot a hog every day and twice on Sunday. I will double lung (a good buck) or neck shoot a doe. Bang-Flop.
The 150 grain Nosler Partiton in .270 caliber delivers the knock out necessary to prevent tracking, provided I do my part behind the trigger. Everything else, from my perspective and what works for me, is experimentation, and I don't want or need to do that any more.
I also shoot a lot of hogs, in the "X" between the ears and eyes, from a steady rest, over corn as bait, at a distance not over 25 yards, with a stainless steel Ruger K77/22RP (.22 long caliber) bolt action rifle that is more accurate with cheap Federal 36 grain lead hollow points than my .270 Winchester or my hunting partner's Anchutz in .22 cal. Bang-Flop. Wait for the sounder to quiet down and go back to eating the corn, and repeat. Small caliber doesn't scare away the pigs and makes quick work for BBQ's.