For my nightstand handgun, a Springfield XD-45.
For concealed carry, pistol is Sig P239 in 9mm and revolver is a Ruger SP101 in .357 Mag.
For single shot handgun, my TC Contender in whatever caliber that is appropriate for what I am hunting.
For hunting with other than a single-shot, my Browning Buckmark in .22 LR for a pistol, and for a revolver it has to be my Freedom Arms model 83 in .454 Casull.
For plinking and target shooting, my Dan Wesson model 15-2 in .357 mag w/6 in. bbl.
If I had to pick only one handgun, it would be a draw between my Ruger old model Blackhawk in .357 mag w/4 5/8 in bbl, or my new model Blackhawk Stainless in .45 LC w/4 5/8 in. bbl.
Each is my favorite when I am shooting or using it; tough question to answer.
Gary