As to actually answering your question. Yes the Rem 100 core-lokt will do a fine job on deer. Just put it in the vitals and you will have a dead deer. I use Sierra 117 gr Pro Hunters in my 25-06 after trying many different bullets. My rifle really likes them, 1 1/4" five shot groups @ 300 yards and 99% of the time it is bang flop on a deer. I really never found any bad deer bullets from 100 to 120 gr for the 25-06. There is just something about the 25-06 that just kills deer DRIT. I have killed deer with about everything thing from 22lr through a 45-70 and the 25-06 is my go to rifle. I helped my hunting buddy do crop damage control hunting for 15 years on a big farm in NC. We learned a thing or two about what did and did not do a good job on deer.