+1 on CW. The best place to start might be a Lee 310 gr mold. It is dirt simple to use and not expensive, the other mold I recommend is a Lyman 429421, that is a 245gr flat base. I suggest trying from 19 to 22 gr of 2400,( with the 300gr) make sure you keep the bullet close to the lands, it is a big deal for accuracy. At this level you won't need gas checks. I am using 20 gr of 2400 and get some under 1" groups @ 50 yards, that will zip right through an old 10" diameter electric pole.
For jacketed, I recommend plain ole 240gr FN Soft point, and my ( as well as several others here) load is 46 gr of IMR 4198. This is stout but not "hot". It is right at factory levels, and I have taken many deer with this load. I must say, that if I could only have ONE whitetail gun/load combination this would be it.
I now use strictly cast in my handi's, but the jacketed in my Marlin. With the lighter bullet try 12-17 gr of Unique or 14-19 gr of Blue Dot. I find that Blue Dot is a very versatile powder in these cast loads. Thes loads run from about 1200 to 1600 fps.