I have the LCR-22 and it's a nice reliable and rugged gun for a good price. I'm not crazy about the trigger, but the ladies who have tried it really liked it. The snake shot for .22lr is pathetic, though.
I ended up paying about 2x the LCR's price for a S&W 351c (7-shot .22 Magnum AirLite Centennial, 11-oz). It's a little smaller, lighter, and a bit more refined in fit, finish, and contour than the LCR. It has a stiff trigger, which can make target shooting a challenge, but I want a stiff trigger for a carry gun. The .22 Magnum shot shells produce a nice softball-size pattern at 9 feet. With Speer Gold Dots I'm getting usable accuracy out to 7 yards for self defense. My groups with the 351c are getting smaller, but the light weight and heavy trigger will require concentration and skill to master.