I shoot the Remington Premier, sighted 3" high at 50 yards. I hold on hair to 125 without adjustment. I have tried these at 200 yards, and found about 13" drop at that range. I hunt an area where only slug guns are legal, and there are some wide open places. Based on my practice, I would not try these much beyond 125. In a really good overall situation, I might try 150 max.
Ben