Have had a lot of fun working on this project, thanks to all who have posted and helped out.
Finally got a pound of H110 to try some loads, wanted to see how it actually compared to Unique when shot over a chronograph.
For comparison's sake:
Hodgdon lists 16.7gr of H110 as delivering 1591fps using Hornady 158gr XTP.
Alliant lists 7.7gr of Unique as delivering 1040fps using a Speer GDHP.
Sierra lists 8.2gr of Unique as delivering 1100fps using their 158gr jhp.
The following were shot out of a Ruger Blackhawk, Win cases, Federal Match primers and 158gr Hornady XTPs. All charges were weighed individually 3 times to ensure uniformity, a light crimp was applied and COL was checked on every case. 15 rounds were fired with each load.
8gr of Unique delivered an average of 1225fps.
16.5gr of H110 delivered an average of 1254fps.