Get the one that you feel COMFORTABLE with!In other words, if it doesn't feel right when you hold it and point it, it just ISN'T going to shoot for you!
Guys are going to give you all kinds of reasons to get a Ruger MarkII, 22/45, S&W, Browning Buckmark, High Standard, etc, etc, etc...
But it all boils down to
FIT!I would rank most of the ones I've listed above as 'quality' handguns, but ONLY the Ruger 22/45 FIT MY HANDS! I liked the grip angle, the size, the location of the controls, etc. AND it shoots the best of any of them for me. I even had a H.S. VICTOR slabside with target sights, grips, etc, but it didn't FIT me, and I couldn't shoot it anywhere near as well as my 22/45 now! The 22/45 was worth 1/2 that VICTOR when I sold it! So cost isn't a factor.
After you decide which one, possibly you get the 22/45, then you'll have cash left over for extra magazines, a thumbsaver magazine loading helper, a holster and ammo! Without the extra mags and ammo you don't get to shoot much!
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Good luck!