I had poor accuracy with .45 Colt in my 16" barrel. At 50 yds. I was shooting groups half the size with the same ammo through a 4-5/8" Ruger Blackhawk.
I suspect the poor accuracy is a result of the poor sights. My barrel has a full length vent rib with a bead front sight. The rear sight is a U-notch, which I find difficult to get a consistent sight picture with. I suspect a traditional square notch, or a peep sight would give much improved performance downrange.
Either that, or I keep thinking I just need to get a low profile red dot and be good to go with either slugs, shot, or .45s.