S8Raz,
My brother and I both shoot the standard 300 grain .452" XTP at a measured muzzle velocity of 1,700 to 1,750 fps. Our field experience has been 100% positive. Mostly broadside heart / lung shots, all inside of 100 yards. Only one deer has gone more than 50 yards from where they were hit, and all died within seconds of being hit.
Two points to make, though.
At really close range, this load does tremendous damage due to impact velocity being near the upper end of the regular XTP's designed range. Nothing wrong with that, just make sure you don't hit the shoulder if you want to keep as much meat as possible.
The one "challenging" shot made with this load was a high angle quartering away shot on a large buck located up a steep slope. Bullet entered at the last rib, passed through the chest cavity and up through the neck. Bullet split the skin on the offside of the neck about 3/4 of the way up, and fell out onto the barn floor as he was being hung. Perfect mushroom, 285 grains retained weight. That is the only 300 grain XTP we have ever recovered.
Good luck, be safe, and have fun out there.
--Ian