I like the 22-250 Handi Rifle as my varminter, which takes a beating in the truck or on the ATV.
I have it in a Handi rifle, in a 98 Mauser conversion, and in a Winchester model 70.
I check cattle multiple times a day, and often dispatch any coyotes I see.
Since it is a very flat shooter, the distance and ballistic calculations are simple
enough for me. I make do with a MILDOT reticle and estimate distance with that.
The 22-250 handi rifle performs well in that range between 250 and 500 yards.
I also use a 257 Weatherby when I am out looking for coyotes and know that spendy
weapon won't receive a beating. But normally it is in the gun safe.
I'll spend a lot of time hunting coyotes in the next two months, before calves drop in March.
I've been known to take the high ground above a canyon meadow where my herd is Wintered,
and take shots beyond 500 yards with my 30/378 Weatherby. That rifle is definitely a specialty
weapon, and I don't recommend it except for that narrow application.
I like the 22-250 for the longer range and simpler ballistics calculations. My buddy likes his 243
for that same reason, and he can drop a coyote well beyond 200 yards with it. Some of the
guys here are making great shots with the 223, and I can't fault them for choosing a
weapon that they can shoot well so inexpensively. I try to be far away from my herd
when I shoot, and the 22-250 allows for that extra distance.
I make my living this way, and the 22-250 Handi has proven itself to be indispensable
in the niche I use it in, which is tending a herd of skittish, pregnant cows.