No problem. Just remember that you don't want to make your bullets too hard. Of course you don't want them too soft either. I use wheel weight lead with no problems. Bullets that are too hard are worse about leading the barrel because the bullet doesn't grip the rifling as well as it should, which allows it to slip across the rifling in the barrel, thus causing lead fouling to develop.
You shouldn't have any problem with lead fouling in the gas block, BTW. If will just get grimy from the bullet lube that burns off in the barrel. If ther's lead fouling, it will be in the barrel. However, I've never had any problems.
Don't use bullet lube that is too hard, and don't jack up the velocities. You really can't run very high velocities in the Blackout anyway, the case is too small.
Reloader 7 works well with cast bullets, as does AA1680 (for subsonic loads around 800 - 1000 fps)