If you are using a 100 grain bullet, 36 grains of IMR 4350 should be fine but note below how seating depth can alter pressure and maximum charge weights.
If you seat the bullets out farther, as long as they are not touching the lands, you tend to lower pressure and velocity for that matter. You also increase case capacity thereby allowing for heavier charges at acceptable pressures, theoretically. Reloading manuals are just guides and you should always begin with the starting loads and keep an eye out for pressure signs before increasing powder charges. I have had rifles where the starting loads were max. Additionally any component change or difference in OAL can make a difference. Like I mentioned earlier, if you are seating your bullets out farther than what is recommended in the manual, chances are your pressure is lower as is your velocity. Only you can tell this though.
As for the OAL, especially with .308 based cartridges in the Handi, I have owned approximately five Handi 243 rifles, two 7mm08, and a couple of 308 rifles and every one of them had long throats, some very long - sort of like the infamous Weatherby freebore. Which is fine for a reloader. I normally start by seating the bullets just shy of the lands if I can get them there and then work back.