Stu, the lovely thing about the 45-70 is the wealth of history, experience, loads and components from all these years to get them shooting. IME it is not a difficult caliber, and most any decent load will do well. Early success is often found in using the larger dia. bullets (my UH is shooting .459 350gr. and 405 gr. just fine, and limited trials with 500s indicate it is fine too but more bullet than I probably need). Several of us use the inexpensive Lee moulds in 350 and 405 as cast and pan lubed (or finger smeared lube). I dont resize cases, just decap, recap, powder charge and seat the bullet, good to go everytime.
Smokeless gets you going with the least trouble, lots of powder choices from 10.0 - 12.0 of Unique on through (for me) 85-100% load of TrailBoss (
) and a bunch of powders in between. Big fast loads of smokeless WILL be more painful than a full charge of Black Powder. It is easy to make an H&R feel like an elephant gun and your shoulder like sausage with nerves. Be aware that there are 3 different loading levels for the 45-70; keep to the 'trapdoor' loads to begin and inch into the 'Marlin Lever Gun' low end if you feel the need for more after some experience. Most wont get to 'Ruger Only', for good reason.
BTW, even at 350gr. each a pound of lead will go fast. I use mostly recycled wheel-weights and a 'dash' of tin (improves the cast), probably about 8-9 BHN (fairly soft), but if you mix in pure lead to 25-50% you will get softer and stretch your soft lead supply. Mine shoot w/o the 'extra-soft' alloy.