44 mag I am assuming. Personally, I would sight in dead on at 25 yards, off the bench, then see where it shoots for you at both 25 and 50 yards, off hand, with what ever type of support you anticipate using while hunting. You may find that with a 25 dead on sight in, the gun will be shooting slightly higher at 50 yards. It's hard to give a blanket statement of bullet drop and rise when shooting off a bench, as how you hold the gun can make a big difference. Personally, I try to rest my wrists over sand bags, as I have found that direct contact between the gun and rest can cause shots to hit differently than fired off hand. When hunting, I usually brace between my knees, or use a handy tree to rest my arm against for support if any range is involved.
Both loads you mention sound good. I have used hard cast heavy weights on a number of deer. They penetrate well, but often do not provide drop in their tracks kills as a good hollow point thru the lungs sometimes can. I have not tried the Speer heavy weight Gold Dot, but if its anything like the 240 XTP, it will work well. With solid cast bullets, I like to hit the shoulder if I can, as it seems to bring them down a little quicker, with minimal meat loss. Real key to handgun hunting big game is pick your shots, and lots of practice. My personal limit is how far I can consistently keep a cylinder full on a paper plate under field conditions.
Larry