For all around shooting, I like the 200 grain cast semi wadcutter at about 800 fps., though 230 grain round nose, cast or jacketed works well also, especially in finicky pistols. Last year, myself and a few friends tested a pretty decent selection of available hollow point self defense ammo. We used bundles of newspaper, soaked in water for a consistent test medium. The 230 grain Gold Dots, and Winchester PDX's seemed to give the best combination of penetration and expansion. Personally, I use the PDX load as my carry load. When carrying a 1911 in moose / black bear country, I load a 240 grain hard cast lead bullet hot, but safe, to about 1000 fps. I took a large whitetail in Maine a few years ago with this load, with thru and thru penetration thru both shoulders.
Larry