I tried 3 and 5 MOA red dots on .357, 44 and 45 Colt Handis and didn't care for them. They were great in low light, but covered too much target to be precise. I can't use irons any more, so I put low power scopes on them. I think they'd be fine deer hunting early or late day at close range. For me, that's a non-issue since, as a rule, I don't use the pistol calibers for deer. I may need a much longer shot.
Pete