Unique has been around like forever, lots of data, lots of success. The primary advantage is that light loads of a fast powder gives one more reloads per 7000gr. (1#); you do the math on more grains of a slow powder. It is not 'the best powder' perhaps, but it has a track record and lots of guys have some. Yes, there are heavier loads than that 10.0-12.0 I mentioned, but my primary reason for that was to get safe, comfy, and likely accurate loads for some initial experience with the cartridge. A lot of fun shooting in a lot of 45-70s have been done with that load for a bunch of years.
Fillers and over-powder wads are another whole topic, and they are NOT the same thing.
There is good, hard documentation now that the use over over-powder wads in smokeless powder loads has resulted in what is called chamber rings. It is a pressure compression, at the position of the base of the bullet while in the cartridge, outward radially to create a 'ring' in the chamber neck. The results are cumulative and may not be noticed until you find hard extraction and the shiny ring on the case neck. At that point your rifle is basically ruined. I will no longer use that technique to 'hold the powder back to the primer'.
Fillers are, well, 'fillers'. A number of things have been used for fillers. They 'fill' the case from the powder level to the bullet base. There has been no documentation that I know of regarding this creating chamber rings. It may have issues with bottleneck cases. Fillers will add to ejecta weight and some may create more recoil. On light loads this may not amount to much.
To avoid messing about I would use the light charge, load it, then raise the muzzle to settle the powder back to the primer, lower to sight position and fire. I have chrono'ed some loads using this technique and got good numbers, less so with the powder all laying on the bottom and the worst with the powder to the bullet base.
After 30 some years of happily using Unique I needed to restock. A friend gifted me some Trail Boss to trial. I didnt buy any more Unique and use the TB in handgun, traditional straight rifle cases and recently bottlenecks. The load density is great, the velo's for my cast bullets fine and I am very satisfied. As always, YMMV.