I have only gone as far up as the Lee 300gr. From what results I got I decided that the 250-270gr bullets were simply all I needed for it.
The link above explains it all very well, and I am now using the 260gr load mentioned at the very bottom of the write up The Myth. It uses like 13grs of HS-6 with the 260, and that load will simply tear out a ragged hole in the bull out to 75yds form my RH. I doubt seriously anything I put one to task on, is going anywhere fast but straight down.