Well I've now tried the RMR with some full powered .454 Casull loads, and it won't zero. Not enough downward adjustment with heavy bullets. In fact with the .45ACP cylinder installed the elevation adjustment is near the bottom to get zeroed as well.
This will need a shim, but I don't know if any are offered. Called Freedom Arms today, and was told that John (Jon... spelling?) would call me back but I didn't hear from him. I'll try again tomorrow, and see if I can get some advice or better yet a shim kit.
Aside from those issues the sight is tough, and seems to hold adjustment well even if it is in the wrong place.