No it's really not different than it's always been. Think about it for a moment, if they really did change the formulation to make it hotter, they would of almost been required to change the name as pressures would be different and SAAMI would require it to be relabeled.
So starting low and working up is always a good idea, and while some guns could digest Mr. Keiths load of 2400 others would lock the cylinders or stick the cases in the chambers. Even Skeeter Skelton wrote in the late 70's he had long ago forgone that charge of 2400 for one a couple of grains less as it was easy on the gun and the hand, and he didn't figure any critter made would even notice the difference.