I've used factory 300HP's and 405SP
both killed, the HP destroyed more meat.
in my ML, a 400gr semispitzer, that I can guarantee you won't expand on deer, makes a 1.5" diameter hole all the way through a deer, from whatever angle, blood trail like a painted highway turn arrow, and little blood shot meat.
I'd say, go with what ever shoots more accurate. in a 45 cal, anything between walking speed, and 1500fps is going to take a deer.