I use .243 on coyotes, sometimes. It tends to be hard on pelts, but I don't skin 'em. Even loaded light, I expect it's not gonna be too fur friendly. I load .223 for a Handi Rifle, and I use 45 grain Sierra Varminters. They make one small entry wound and no exit. If you have the resources, I'd recommend getting the .223. It might take some looking, but brass and bullets can be found. You just need a few to get ya started...