I dont have the 454 but have been using Trail Boss in everything, straight case revolver 38/357Mag, 44Mag, 45ACP and LC with std. pistol primers as well as in my rifle calibers inc. 357Mag,, 38-55 and 45-70.
No primer issues in my guns and the loads work just fine, and thats at more than the 70% 'start load' density that Hodgdon recommends.