2400 is generally an excellent powder for the 357. Your load range is about 11 to 13.5 grains max and should be about 1500 fps from your barrel. If the lube is decent you should not have a leading problem. Also, if you go down to about 3 gr of Unique you should have a subsonic load that is extremely quiet. The inertia of a 180 gr bullet is surprising, even at 1400 fps it will zip right through a deer. Just find the most accurate load. I would suggest seating it long, just short of touching the rifling, and crimp it some. I find that some crimp helps the accuracy considerably for me, makes the burn more uniform. I shoot a similar bullet over 3.6 gr of Unique in 38 cases for small game / plinker loads, mine stay under 1 " @ 50 yards. My deer load is a 158 gr XTP over 13.8 gr of 2400. My grandson has taken 3 deer with that load so far.