In general, a .224 12 twist barrel is the choice for 55/60gr bullets... heavier bullet usually want a slower twist.
I've been a 22 Varminter/22-250 fan since I my first one inb the 60's. I never really considered it a deer cartridge in the Roclkies where I lived, but it can exert so much hydrostatic shock with the right hand loads and light bullets it would be quite capable.
Note on Encore 22-250 factory barrels: When the Encore first came out I ended up buying 3 different 15" 22-250 barrels to get one that would shoot well. First two were total crap IMO - maybe Okm for other folks, but I couldn't get any hand load to shoot well enough in them for my uses. Last one was acceptable with the right loads worked up for it. A custom barrel that followed put that last factory barrel to shame though. My use for them was long range predators and varmints though, not deer. I almost always shot 55gr bullets in all of my 22V's/22-250's over the years, but also some 50's, 46's and a few 33's.