I shoot hand loads only in my 25-06. I use Retumbo powder and Nosler 110gr bullets. Can't remember the powder charge off the top of my head, I'm on vacation so I can't look it up, but it is in the Nosler manual. The 25-06 makes a good long range gun, and can easily reach out to 700 yards. At that range it still has enough energy and velocity left to be effective on Wolf and Coyote. If I lived in the lower 48 I would not hesitate to shoot Whitetail with it at that range. Alaskan Wolves have a body the size of a Whitetail, and that is what I use my 25-06 on.