I don't think the last deer I shot was 25 yards away......but my wife busted a woodchuck a while back at a range finder measured 440 yards. He coulda been a 10 point buck as well as a woodchuck. I can shoot into a safe berm 300 yards off my back deck I don't think I own a firearm that hasn't been shot at the gongs up there. I've even chucked slugs up there with the scatter guns and muzzle loaders...including flintlocks. Every rifle ever made by mankind shoots a rainbow. Some much flatter than others, granted, but still a rainbow. All I say is take the time....and yes money...and learn your guns. All of them.
I like to hang around the County Range a week or two before deer season. I watch folks breaking out rifles, taking one or two shots at a 100 yard target and going home. I doubt if one out of five could tell you where that bullet was going to be at 25, 50, 150, or 300. The box of ammo is probably priced at 7.95, that's how long they've had it. I guess I'm a snob, but I can tell you what the holdover or under will be for just about everything I shoot. I have a very distinct advantage. I can shoot anytime weather and honey dos permit.
One more thing. No, a bullet that can punch a hole in paper at 500 yards is not certain to kill something that far. But then there are rifles and bullets that can and do kill as far as you can see. I should add, the "100 yard woods rifle", the .45-70 is among them. Yes, you have to "walk" a .45-70 out there to learn what it's doing, but once there you can duplicate the accuracy from just about any other rifle. The Handi .45-70 is an accurate, long range beast...get on it and learn it.
Pete