We had an SR22, and except for cross eye dominace like your wife has, we found the same thing as you, she just shot to a different place than I do.
We adjusted the sights for her, (it was her gun), and shortly afterward traded it in for a S&W Victory 22, that simply worked for both of us.
Our thoughts were should either one of us find themselves in a situation of a home invasion we HAVE to be able to use any gun in the house without any difficulty at all. It is, was, and will remain the primary reason we own firearms to begin with, and that reason must apply to ALL of them, even target guns, shotguns, rifles, aircraft carriers, and Sherman Tanks. If we ever get any of those, we both need to be profient. DOGS OR GUNS, IF YOU CAN'T CONTROL IT< DON'T OWN IT!