OK, I'll be one of the naysayers and recommend going with the genuine Czech made CZ-75. About the only exception to this would be the Solothurn made AT-84. Both have forged frames and slides, safeties in the right place, and parts are easily available to repair them if needed. Plus you can convert the real one to .22LR if you want to. I wouldn't give up my '78 model for a whole truckload of the Italian copies!
Hate to tell you this, Nobade, but the frames on CZ pistols are not forged. The slides are forged, but the frames are made via investment casting. The exception here is the aluminum frames, which are forged. The frame of any steel CZ pistol is cast, not forged.
Also, Tangfolio did make a .22 lr conversion kit at one point in time, but you don't see them state-side very often. I have only seen one, it was mounted on a CZ-75 (pre-B) frame. I'm still kicking myself for not buying that one (had both 9mm and .22 setups, but had the .22 mounted).
That said, don't worry about cast frames. Proper investment casting will produce a gun at least as strong as any forged gun, if not a stronger gun. All of Ruger's steel frames are investment cast. Caspian uses cast frames in some 1911 pistols. Dan Wesson's SuperMags are built on cast frames.
Back to the CZ vs. Tangfolio debate, it's really down to which one fits you better. If you can shoot both, that would be the best way to decide, but handle both at the very least. Like Nobade, I wouldn't trade my CZ-75 (B model) for a "truckload of Italian copies", but I also wouldn't reject the idea of buying the Tangfolio.